NIRT: gated transport through carbon nanotube membranes

Issued as final reportUniversity of California, Berkele

Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces.

Although adhesive interactions between cells and nanostructured interfaces have been studied extensively, there is a paucity of data on how nanostructured interfaces repel cells by directing cell migration and cell-colony organization. Here, by using multiphoton ablation lithography to pattern surfaces with nanoscale craters of various aspect ratios and pitches, we show that the surfaces altered the cells focal-adhesion size and distribution, thus affecting cell morphology, migration and ultimately localization. We also show that nanocrater pitch can disrupt the formation of mature focal adhesions to favour the migration of cells towards higher-pitched regions, which present increased planar area for the formation of stable focal adhesions. Moreover, by designing surfaces with variable pitch but constant nanocrater dimensions, we were able to create circular and striped cellular patterns. Our surface-patterning approach, which does not involve chemical treatments and can be applied to various materials, represents a simple method to control cell behaviour on surfaces

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

The integration of in vitro cardiac tissue models, human induced pluripotent stem cells (hiPSCs) and genome-editing tools allows for the enhanced interrogation of physiological phenotypes and recapitulation of disease pathologies. Here, using a cardiac tissue model consisting of filamentous three-dimensional matrices populated with cardiomyocytes derived from healthy wild-type (WT) hiPSCs (WT hiPSC-CMs) or isogenic hiPSCs deficient in the sarcomere protein cardiac myosin-binding protein C (MYBPC3-/- hiPSC-CMs), we show that the WT microtissues adapted to the mechanical environment with increased contraction force commensurate to matrix stiffness, whereas the MYBPC3-/- microtissues exhibited impaired force development kinetics regardless of matrix stiffness and deficient contraction force only when grown on matrices with high fibre stiffness. Under mechanical overload, the MYBPC3-/- microtissues had a higher degree of calcium transient abnormalities, and exhibited an accelerated decay of calcium dynamics as well as calcium desensitization, which accelerated when contracting against stiffer fibres. Our findings suggest that MYBPC3 deficiency and the presence of environmental stresses synergistically lead to contractile deficits in cardiac tissues

High-Speed Photothermal Patterning of Doped Polymer Films.

Organic semiconductors (OSCs) offer a new avenue to the next-generation electronics, but the lack of a scalable and inexpensive nanoscale patterning/deposition technique still limits their use in electronic applications. Recently, a new lithographic etching technique has been introduced that uses molecular dopants to reduce semiconducting polymer solubility in solvents and a direct-write laser to remove dopants locally, enabling rapid OSC etching with diffraction limited resolution. Previous publications postulated that the reaction that enables patterning is a photochemical reaction between photoexcited dopants with neutral solvent molecules. In this work, we analyze the photoinduced dissolution kinetics of F4TCNQ doped P3HT films using time-resolved in situ optical probing. We find two competing mechanisms that control de-doping and dissolution: the first is the photochemical reaction posited in the literature, and the second involves direct heating of the polymer by the laser, inducing increased solubility for both the polymer and dopant. We show that the wavelength-specific photochemical effect is dominant in low photon doses while the photothermal effect is dominant with high excitation rates regardless of laser wavelength. With sufficiently high optical intensity input, the photothermal mechanism can in principle achieve a high writing speed up to 1 m/s. Our findings bring new insights into the mechanisms behind laser direct writing of OSCs based on dopant induced solubility control and enable ultraprecise fabrications of various device configurations in large-scale manufacturing

Ultra-Short Pulsed Laser Annealing Effects on MoS2 Transistors with Asymmetric and Symmetric Contacts

The ultra-short pulsed laser annealing process enhances the performance of MoS 2 thin film transistors (TFTs) without thermal damage on plastic substrates. However, there has been insufficient investigation into how much improvement can be brought about by the laser process. In this paper, we observed how the parameters of TFTs, i.e., mobility, subthreshold swing, I on /I off ratio, and V th , changed as the TFTs’ contacts were (1) not annealed, (2) annealed on one side, or (3) annealed on both sides. The results showed that the linear effective mobility (µeff_lin) increased from 13.14 [cm 2 /Vs] (not annealed) to 18.84 (one side annealed) to 24.91 (both sides annealed). Also, I on /I off ratio increased from 2.27 x 10 5 (not annealed) to 3.14 x 10 5 (one side annealed) to 4.81 x 10 5 (both sides annealed), with V th shifting to negative direction. Analyzing the main reason for the improvement through the Y function method (YFM), we found that both the contact resistance (R c ) and the channel interface resistance (R ch ) improves after the pulsed laser annealings under different conditions. Moreover, the Rc enhances more dramatically than the R ch does. In conclusion, our picosecond laser annealing improves the performance of TFTs (especially, the R c ) in direct proportion to the number of annealings applied. The results will contribute to the investigation about correlations between the laser annealing process and the performance of devices. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.1

MICRO/NANOSCALE STRUCTURE FABRICATION BY DIRECT NANOIMPRINTING OF METALLIC AND SEMICONDUCTING NANOPARTICLES

ABSTRACT In this paper, we present our recent development of direct nanoimprinting of metal and semiconductor nanoparticles for a simple but high-throughput fabrication of micro/nanoscale structures. Nanoparticle suspension with self-assembledmonolayer (SAM) protected-nanoparticles (Au, Ag, and CdSeZnS core-shell quantum dots) suspended in alpha-terpineol carrier solvent are used as solutions for direct nanoimprinting. Polydimethylsiloxane (PDMS)-based soft imprinting molds with micro/nanoscale features are used. Process and material flexibility enable a very low temperature (80 ºC) and low pressure (5psi) nanoimprinting process and results in superfine features from micrometers down to ~100nm resolutions. We will show the geometrical and electrical characterization of nanoimprinted structures and demonstrate working electronic components such as resistors or organic field effect transistors (OFET). INTRODUCTION Recently, nanoimprinting has been introduced as an inexpensive and high-throughput nanopatterning metho